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The most reliable midsize luxury cars are jack-of-all-trades vehicles. They offer a long list of luxury features, good performance, safety, and comfort. These luxury midsizers can serve as family cars or commuter cars. They blend into virtually every surrounding. The top vehicles in this segment include the Lexus ES 350, BMW 5 Series, and Mercedes-Benz E Class. These cars have been around for a long time. They’re popular because of their nameplates and because they generally live up to the hype.   

Each one has a proven track record of performance and offers an element of prestige. They are also among the most reliable cars in this segment, as reported by iSeeCars. Whether you’re buying new or used, iSeeCars says they are the top midsize luxury cars for reliability, safety, and resale value.  

Is the Lexus ES 350 a good midsize sedan?

brown leather 2022 Lexus ES 350 interior midsize luxury car
2022 Lexus ES interior | Lexus USA

The ES 350 has long been one of Lexus’ most popular models because of its features and solid reliability. As the company’s midsize car, it prioritizes comfort over performance, leaving that role to the smaller IS 350. It’s also more affordable than the flagship LS sedan but offers almost the same level of luxury at a more affordable price.

The only engine offered on the ES 350 is the 3.5-liter V6. It’s a gem, smooth and powerful, putting out 306 horsepower. Available with front or all-wheel drive, it hustles to 60 mph in 6.1 seconds. 

The 2022 ES 350 gets a number of updates. Outside, it receives a new grille and LED headlights. Inside, the infotainment system loses the clunky touchpad controller in favor of a 4.3-inch touchscreen. The Lexus Safety System+ 2.5 package now features a host of driver’s aids, including Intersection Turning Assist, an improved collision mitigation system with better pedestrian recognition, better adaptive cruise control, and lane keeping.  

Prices start at $40,950 for a new Lexus ES 350 and range from $28,000 to $46,000 used. iSeeCars gives the ES 350 a score of  8.9/10 for reliability, 8.9/10 for value, and 10/10 for safety. 

BMW 5 Series

The BMW 5 Series is the most sporting of the three top-rated midsize luxury cars. The entry-level 530i produces 248 horsepower from a 2.0-liter turbocharged four-cylinder, while the M550i almost doubles that number, squeezing 456 horsepower from a 4.4-liter twin-turbo V8. Regardless of which model, it will be plenty quick. It also handles well with firm handling and a balanced chassis. Stopping power is also good, taking only 108 feet to stop from 60 mph. 

As a midsize luxury car, the BMW 5 Series offers luxury and a number of driver aids and tech features, including the usual host of driver aids and thoughtful touches like wireless phone charging. The starting price is $54,000 for a new one with used models ranging between $32,000 and $64,000. iSeeCars gives it an 8.7/10 for reliability and 7.0/10 for value.    

Mercedes E-Class

Mercedes-Benz’s E-Class sedan has long offered a solid, vault-like feel and good performance. The current model is no different. It also offers a smooth ride and attractive styling. Like the BMW, it offers a variety of engines, from the turbocharged four-cylinder of the E350 that makes 255 horsepower, and a hybrid system with a 362 horsepower inline-six.   

On the road, the E-Class feels solid and composed. It’s smooth with effortless power. While not as performance-oriented as the BMW 5 Series, it still has moves. With either rear-wheel or all-wheel drive, it puts the power down and handles twisty roads with ease. 

Prices start at $56,000 for a 2022 Mercedes-Benz E-Class and range from $35,000 to $81,000 used. iSeeCars gives the E-Class a score of  8.7/10 for reliability, 6.9/10 for value, and 10/10 for safety.

Which midsize luxury car is the most reliable?

Judging by reliability scores, the Lexus ES 350 is the most reliable. It’s also the most comfort-oriented, making it an ideal midsize luxury car for someone who spends a lot of time commuting or is more interested in getting to their destination than driving. 

If you’re the kind of person that likes driving and wants to spice up your commute, the BMW 5 Series makes the best option. It still gets a great overall reliability score while offering more dynamic handling and performance. 

Or, for a compromise between luxury and performance, the Mercedes-Benz E-Class makes an excellent pick. It offers effortless performance and is fun to drive while also offering solid luxury credentials.